PubMed Query on Celution
PubMed Query on Celution

PubMed Query on Celution

Written by Fas Kuiters

Recently the question was raised whether anybody ever had encountered a negative scientific -peer reviewed- study involving Cytori´s processing device Celution, which had been-as written- unfavorable i.e. negative in its conclusions.

In order to be able to give a substantiated answer to this question, one really has to know first which scientific- peer reviewed- papers do exist on the subject, so since I have been rather involved with the art of interrogating databases, I did so with the pretty substantial- and complete PubMed database. Off late the DB has been returning more and more publications from Private Investigator clinics and it is very likely that the funnel of these investigations has been growing and growing and beats the quality of Cytori´s past own investigations by many many miles. But also, that funnel will also "spit out" more results in the near future- Cugat -as an example- is expected any day now with his ACL results.

So- it starts to be interesting to put FOCUS on what is being issued in the various scientific journals of the globe, in order to be able to glimps at Cytori´s platform future. 


In order to do so- glimpsing on what is ongoing- I did a query on the PubMed database with the search parameter " Celution" at present- end July 2016- 19 positives are returned, which you will find listed below.  Going forward the list will stop at 20....but will start with the latest published article and will delete the eldest. 

Negative Conclusions?

To answer that question- yes, there is one. A study from Finland I believe, where the investigators used "water assisted liposuction" for their scientific comparison with manual extraction of supercharged fat in reconstruction. All I recall is, that I inquired in Finland, why the hell they did this study with this lipo device. The PI answered me that he did the study, since he was a friend of Adam Katz- Co-founder of StemSource. For insiders, this is all explanatory...Evil

The Query Results

pubmed: celution

11 December 2019

NCBI: db=pubmed; Term=Celution
  • Second-look arthroscopic findings of cartilage and meniscus repair after injection of adipose-derived regenerative cells in knee osteoarthrits: Report of two cases.
    Related Articles

    Second-look arthroscopic findings of cartilage and meniscus repair after injection of adipose-derived regenerative cells in knee osteoarthrits: Report of two cases.

    Regen Ther. 2019 Dec;11:212-216

    Authors: Onoi Y, Hiranaka T, Nishida R, Takase K, Fujita M, Hida Y, Fujishiro T, Okamoto K

    Background: The purpose of this study was to use second-look arthroscopic findings and clinical assessment to determine outcome in two cases of knee osteoarthritis treated by intra-articular knee injection of adipose-derived regenerative cells (ADRCs).
    Case presentation: This study involved two patients who received ADRC therapy for knee osteoarthritis and completed the six-month post-treatment follow-up period. For each treatment, 130 mL of subcutaneous adipose tissue was harvested using tumescent liposuction technique and manual aspiration of tissue from the thigh using a suction cannula under local anesthesia in the operating room. The adipose tissue harvested was processed using the Celution® Centrifuge in a dedicated cell processing room. The ADRCs were injected into the articular cavity of both knees for one patient and into a single affected knee in the second patient (three joints). Pain and knee function were assessed using a Visual Analogue Scale (VAS) and the Knee Outcome in Osteoarthritis Score (KOOS) respectively. The cartilage defect was assessed by direct visualization (arthroscopy). No serious adverse events were reported throughout follow-up. Pain and knee function were significantly improved from baseline in all treated knees at one, three and six months after ADRCs. At six-months after ADRCs treatment, the second-look arthroscopy showed that almost all the cartilage defect areas were covered by regenerated cartilage, some cartilage fibrillation area was reduced, and meniscus tear areas were repaired.
    Conclusions: Cartilage and meniscus repair were observed six-months after ADRCs therapy under second-look arthroscopy. It was shown that a single administration of ADRCs might be effective as a treatment for knee osteoarthritis.

    PMID: 31489345 [PubMed]

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