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TOPIC: In ALS Research- Glucose Metabolism gets Center Stage

In ALS Research- Glucose Metabolism gets Center Stage 18 Jan 2020 10:00 #13417

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I recently quoted some remarks from the former Chief Editor of the New England Journal of Medicine about the reliance one can have on corporate sponsored clinics- still the NEJM is the highest impact medical journal followed by the Lancet and JAMA (Journal of the American Medical Association)

In this last Journal a publication appeared recently on the direction of ALS research. I lost my best buddy in Holland a few months ago at the age of 71 and am strongly convinced that besides a genetic component, also lifestyle had a major role to play in this (my believe) . Research is also going into that direction by the "establishment"-

With a dearth of treatment options, Craft and others are also turning to lifestyle interventions that may have beneficial metabolic effects in both the body and brain. Craft recently published results of a pilot crossover trial comparing a modified version of the ketogenic diet incorporating Mediterranean diet elements with a low-fat diet among patients with memory complaints or mild cognitive impairment.

Six weeks after completing the modified ketogenic diet, patients had improved Alzheimer disease biomarkers in their cerebrospinal fluid. “With the ketogenic diet, we are moving the β-amyloid in a healthier direction,” Craft said. Patients also had better blood flow to the hippocampus and improved body-wide insulin sensitivity. A larger trial of the modified ketogenic diet is now under way.

Craft is also exploring the benefits of exercise, which has been shown to improve cognition and insulin sensitivity in other populations, as a therapy for patients with Alzheimer disease. In Luchsinger’s view, there isn’t enough evidence yet to recommend lifestyle modifications for Alzheimer disease treatment, although he noted that a recent Finnish trial provided proof of concept that lifestyle interventions may benefit those at risk for dementia

Anyway- this is quite interesting and "revolutionary" for the establishment-

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:
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